Fig. 8

FUS and circ_002136 knockdown combined with miR-138-5p over-expression suppressed angiogenesis in vivo (a) The co-effect of FUS, circ_002136, and miR-138-5p on angiogenesis in vivo was evaluated by the Matrigel plug assay. (a) The amount of hemoglobin was measured after the combined treatment of FUS, circ_002136, and miR-138-5p. Data are presented as the means ± SD (n = 3, each group). ^**P < 0.01 vs. control group; ^##P < 0.01 vs. the FUS (−) group; ^&&P < 0.01 vs. the circ_002136 (−) group. ^§§P < 0.01 vs. the miR-138-5p (+) group. (c) A schematic representation of the FUS/circ_002136/miR-138-5p/SOX13/SPON2 axis involvement in the mechanism mediating the GEC angiogenesis