Fig. 4
From: SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production
SHMT1 inhibits lung metastasis of HCC cells in nude mice. (a) HCCLM3 cells overexpressing SHMT1 or those in control group were injected into nude mice through tail vein, to evaluate the effect of SHMT1 overexpression on in vivo metastasis of HCCLM3 cells. HE staining and IHC staining of AFP were performed to identify the lung metastatic nodules formed by HCCLM3 cells. (b) Hep3B cells with or without SHMT1 knockdown were injected into nude mice through tail vein, to evaluate the effect of SHMT1 knockdown on in vivo metastasis of Hep3B cells. HE staining and IHC staining of AFP were performed to identify the lung metastatic nodules formed by Hep3B cells. *P < 0.05