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Table 1 Correlation analysis between the clinical features and SHMT1 expression in HCC

From: SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production

Characteristics of patients No. of patients SHMT1 level P
Low High
Age (y) < 60 86 47 39 0.149
≥60 34 24 10
Sex Male 103 60 43 0.187
Female 17 13 4
HBV infection Absent 15 10 5 0.587
Present 105 61 44
Cirrhosis Absent 23 18 5 0.058
Present 97 53 44
AFP level < 20 36 17 19 0.105
≥20 84 54 30
Tumor size (cm) < 5 44 22 22 0.129
≥5 76 49 27
Vascular invasion Absent 56 26 30 0.009*
Present 64 45 19
Edmondson-Steiner grading I + II 76 39 37 0.021*
III + IV 44 32 12
TNM tumor stage I + II 39 17 22 0.019*
III + IV 81 54 27
  1. HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha fetoprotein; TNM, tumor-node-metastasis. * Statistically significant