SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production

Table 1 Correlation analysis between the clinical features and SHMT1 expression in HCC

Characteristics of patients		No. of patients	SHMT1 level		P
Characteristics of patients		No. of patients	Low	High	P
Age (y)	< 60	86	47	39	0.149
Age (y)	≥60	34	24	10	0.149
Sex	Male	103	60	43	0.187
Sex	Female	17	13	4	0.187
HBV infection	Absent	15	10	5	0.587
HBV infection	Present	105	61	44	0.587
Cirrhosis	Absent	23	18	5	0.058
Cirrhosis	Present	97	53	44	0.058
AFP level	< 20	36	17	19	0.105
AFP level	≥20	84	54	30	0.105
Tumor size (cm)	< 5	44	22	22	0.129
Tumor size (cm)	≥5	76	49	27	0.129
Vascular invasion	Absent	56	26	30	0.009*
Vascular invasion	Present	64	45	19	0.009*
Edmondson-Steiner grading	I + II	76	39	37	0.021*
Edmondson-Steiner grading	III + IV	44	32	12	0.021*
TNM tumor stage	I + II	39	17	22	0.019*
TNM tumor stage	III + IV	81	54	27	0.019*

HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha fetoprotein; TNM, tumor-node-metastasis. ^* Statistically significant

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