Fig. 2
Circ_0000190 inhibits the progression of MM. a Transfection efficiency of circ_0000190over-expression and knocking down were determined by qRT-PCR. *** circRNA or sh-circRNA vs. control, P < 0.001. b The CCK8 assay detects the effect of circ_0000190and sh-circ_0000190on cell viability of H929 cells. ** circRNA or sh-circRNA vs. control, P < 0.01. c The CCK-8 assay detects the effect of circ_0000190 and sh-circ_0000190 on cell viability of MM. 1S cells. ** circRNA or sh-circRNA vs. control, P < 0.01. d EdU labeling assay detects the effect of circ_0000190and sh-circ_0000190 on cell proliferation. ** circRNA or sh-circRNA vs. control, P < 0.01. e Flow cytometry apoptosis method detects the effect of circ_0000190 and sh-circ_0000190 on cell apoptosis. f Flow cytometry detects the effect of circ_0000190 and sh-circ_0000190 on cell cycle of H929 cells. ** circRNA or sh-circRNA vs. control, P < 0.01. g Flow cytometry detects the effect of circ_0000190 and sh-circ_0000190 on cell cycle of MM. 1S cells.** circRNA or sh-circRNA vs. control, P < 0.01. (H) IF staining detects the effect of circ_0000190 and sh-circ_0000190 on the expression of MAPK4. i Western blot analysis detects the effect of circ_0000190 and sh-circ_0000190 on the expression of MAPK4, CDK6, CDK4, Cyclin D1 and Cyclin E, p21Cip1. **P < 0.01, ***P < 0.001