Fig. 7
Prognostic role of miR-223 in ovarian cancer patients. The differences of miR-223 (a) and PTEN mRNA (b) expression between cDDP-sensitive (PFS<6) and –resistant (PFS>6) patients in ovarian cancer specimens was shown. c Immunohistochemistry analysis of PTEN and p-AKT. Representative photographs are shown (× 200 magnification). d, e A Kaplan-Meier analysis of PFS for ovarian cancer patients with the corresponding expression profiles of miR-223 (d) and PTEN (e) was shown. PTEN and miR-223 expression were inversely correlated in EOC samples (n = 62). f A plot of the relative expression of miR-223 vs PTEN showed an inverse correlation between them. g Correlation index R2 were calculated using Spearman rank test (R2 = 0.3169). h A Kaplan-Meier analysis for PFS of ovarian cancer patients according to anticorrelation miR-223 and PTEN expression. i Exosomic miR-223 in 12 EOC patients at the time of primary and recurrent was measured. *P < 0.05, **P < 0.01