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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Landscape of tumor suppressor long noncoding RNAs in breast cancer

Fig. 6

ZNF217-EZH2-H3K27me3 axis epigenetically suppresses the expression of EPB41L4A-AS2 in breast cancer. a The ZNF217 knockdown efficiencies of three siRNAs were examined. b The expression of EPB41L4A-AS2 was upregulated when ZNF217 expression was knocked down in MDA-MB-231 cells. c A Co-IP assay showed that ZNF217 can directly bind to EZH2. d ChIP- PCR showed that EZH2 could bind to the promoter region of EPB41L4A-AS2. e ChIP-PCR showed that H3K27me3 could bind to the promoter region of EPB41L4A-AS2. f A significant H3K27me3 enrichment peak occurred at the EPB41L4A-AS2 locus in the breast cancer cell data from ENCODE. ***P < 0. 001; **P < 0. 01; *P < 0.05. Data represent at least three independent experiments

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