Fig. 8

LINC00968 was lowly expressed, whereas WNT2 was highly expressed in breast cancer tissues and cells. LINC00968 targeted and negatively regulated WNT2 via the transcriptional repressor HEY1. Overexpressed LINC00968 reduced drug resistance, migration, invasion and epithelial-mesenchymal transition of breast cancer cells through inhibiting the activation of the Wnt2/β-catenin signaling pathway via suppression of WNT2