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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Fig. 5

Zoledronic acid promotes cell cycle arrest of cervical cancer cells derived CSCs. Flow cytometry analysis of the cell cycle distribution of HeLa cells derived CSCs treated or not with 10, 20, and 30 μM zoledronic acid, respectively (a). The histograms show the proportions of cell cycle distribution in G1, S, and G2/M phase of cervical cancer cells derived CSCs (b). Western blot analysis of CyclinD1 and CDK4 in cervical cancer cells derived CSCs treated or not with zoledronic acid (10, 20 and 30 μM, respectively) (c). Control vs. 10, 20, and 30 μM of zoledronic acid: * P < 0.05, ** P < 0.01. Results are mean values ± SD of independent experiments performed in triplicate

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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