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Table 1 Overview of collagen type I, II, III, V, VI, XXIV and XXVII and their distribution in healthy tissue, cancer tissue, tumor promoting effects and liquid biomarker potential

From: Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Collagen type Description Reference
Collagen type I:
• Tissue distribution Main organic compound in bone.
Also present in soft tissue.
[75]
• Tissue distribution in associated cancers Major implications in bone cancer, and metastasis from bone to other solid tumors. Also described in breast, colorectal, ovarian, lung and pancreas cancer. [21, 23, 24, 76,77,78,79,80,81,82,83,84,85]
• Tumor promoting effects Associated with apoptosis, invasion, metastasis and proliferation. [81,82,83,84,85]
• Liquid biomarker potential Associated with bone metastasis in prostate and breast cancer patients. Increased in serum from colorectal, lung and pancreas cancer patients. [21,22,23,24,25]
Collagen II
• Tissue distribution Main collagen in cartilage. [86]
• Tissue distribution in associated cancers Associated with chondrosarcoma [88,89,90]
• Tumor promoting effects Associated with cell death and survival [88,89,90]
• Liquid biomarker potential n/a  
Collagen type III
• Tissue distribution Primarily found in the vascular system, intestine, liver, skin and lung. [86]
• Tissue distribution in associated cancers Implications in breast, colorectal, HNSCC and pancreas cancer. [21, 22, 34, 91,92,93,94]
• Tumor promoting effects Associated with invasion, metastasis, migration and proliferation. [73, 74, 82]
• Liquid biomarker potential Augmented in serum from ovarian, breast, colorectal, melanoma and pancreas cancer patients. Able to predict pancreas cancer patients most likely to respond to treatment. [21, 24, 94, 131]
Collagen type V
• Tissue distribution Primarily in same tissues as collagen type I and III. [86, 95]
• Tissue distribution in associated cancers Associated with breast cancer. [96]
• Tumor promoting effects Associated with tumor growth. [96]
• Liquid biomarker potential n/a  
Collagen type VI
• Tissue distribution Present in many tissues such as adipose, cartilage, skin, cornea, tendon, lung, skeletal muscle and dermis. [97]
• Tissue distribution in associated cancers Described in breast, colorectal, ovarian, gliomas, melanomas and pancreas cancer. [98]
• Tumor promoting effects Associated with apoptosis, drug resistance, inflammation, invasion, metastasis and proliferation. [97,98,99,100,101,102,103,104,105,106]
• Liquid biomarker potential Augmented in serum from melanoma and pancreas cancer patients. [132, 133]
Collagen type XI
• Tissue distribution Distributed in low levels in skeletal muscle, trabecular bone, tendons, testis, trachea, articular cartilage, lung, placenta and brain. [107,108,109,110,111,112,113,114]
• Tissue distribution in associated cancers Extremely augmented in colorectal and HNSCC cancer. Also associated with breast, gastric, lung, ovarian and pancreas cancer. [107,108,109,110,111,112,113,114]
• Tumor promoting effects Highly implicated in CAF biology. Also associated with invasion, metastasis and proliferation. [107,108,109,110,111,112,113,114,115,116,117,118,119]
• Liquid biomarker potential n/a  
Collagen type XXIV
• Tissue distribution Distributed in ovaries, testis, liver, spleen, kidney, muscle and bone. [120,121,122]
• Tissue distribution in associated cancers Associated with HNSCC. [123]
• Tumor promoting effects Associated with cell differentiation. [123]
• Liquid biomarker potential n/a  
Collagen type XXVII
• Tissue distribution Expressed in the developing eyes, ears, lungs, heart and arteries. [124,125,126]
• Tissue distribution in associated cancers n/a  
• Tumor promoting effects n/a  
• Liquid biomarker potential n/a  
  1. HNSCC Head and neck squamous cell carcinoma, n/a not available