Fig. 6

A negative correlation exists between the expression of CRIP1 and Fas in CRC tissues. a. Overexpression of CRIP1 is accompanied with the low expression of Fas, whereas silencing of CRIP1 is followed by the high expression of Fas in subcutaneous tumors. b. A reversed expression pattern of CRIP1 and Fas was detected in CRC tissues. Left panel: CRIP1 is usually overexpressed in CRC tissues while Fas highly expressed in its adjacent normal mucosa. The middle panel: the percentage of high or low Fas expression specimens in normal and cancer tissues. The right panel: the percentage of high or low Fas expression specimens in high or low CRIP1 expression specimens. c. A hypothetical model illustrating that CRIP1 interacts with Fas and stimulates the ubiquitin-mediated degradation of Fas to inhibit apoptosis of CRC cells