Fig. 6
From: CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
Overexpression of CCDC106, but not S130/147A mutant, enhances the growth of xenograft tumors. BALB/c nude mice were injected with 5 × 106 SiHa cells expressing empty vector, CCDC106 or S130/147A mutant. a Dynamic volume (mean ± S.D., n = 6) of xenograft tumors at different timepoints after injection. b Images of the xenograft tumors at 49 d after injection. c Average weight (mean ± S.D., n = 6) of xenograft tumors at 49 d after injection. d WB analysis of the expression of Bax, Bcl2, p53 and CCDC106 in tumors. e Real-time PCR analysis of the mRNA expression levels of Bcl2 and Bax in tumors. Differences between control and experimental groups were analyzed by Student’s t-test; *p-value ≤0.05, **p-value ≤0.01, and ***p-value ≤0.001