Fig. 7
From: Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression
Intercellular transfer of miR-3188 by exosomes inhibits tumor growth in vivo. a Exosomes were loaded with miR-3188 mimics and used to treat the CAL27 xenografts-bearing mice. The graphics of xenografts, tumor growth curve and tumor weights showed that intra-tumor injection of miR-3188-loaded exosomes inhibited xenograft tumor growth in nude mice. b Immunohistochemical analysis of BCL2 expression, Ki-67 staining, Caspase3 expression and TUNEL assay in the xenografts (Scale bar: main = 50 μm; insert = 20 μm). (NC, negative control. ns, no significant difference, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)