Fig. 7

LBH589 inhibits NF1 MPNST cell growth through HMGA2-MSI2 interactions. a Cell viability was assessed by CCK-8 assays. LBH589 inhibits cell proliferation activity, while overexpression of HMGA2 reverses cell proliferation activity. The data represent the mean ± SD of three independent experiments. *P < 0.05 by Student’s t-tests. b and c WB and qRT-PCR were performed to detect the indicated protein and mRNA expression levels in NF1 MPNST cells. Bars represent the SEM. **P < 0.05 by Student’s t-tests