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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma

Fig. 8

Modulation of ANXA11 partially abolishes AGAP2-AS1 or miR-16-5p-mediated cellular processes in HCC. a miR-16-5p-overexpressing or AGAP2-AS1-suppressive HCCLM3 cells that were transfected with empty vector (EV) or ANXA11 overexpression plasmid were subjected to western blot for ANXA11. miR-16-5p-suppressive or AGAP2-AS1-overexpressing Hep3B cells that were transfected with scrambled siRNA or ANXA11 siRNA were subjected to western blot for ANXA11. ANXA11 restoration abrogated the effects of miR-16-5p overexpression or AGAP2-AS1 knockdown on cell proliferation (b), migration (c), invasion (d), apoptosis (e) and EMT process (f) of HCCLM3 cells. ANXA11 knockdown reversed the promotive effects of miR-16-5p knockdown or AGAP2-AS1 overexpression in Hep3B cells (b-f). *P < 0.05

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