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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors

Fig. 2

FOXM1 de-phosphorylation in response to Aurora A/PLK1/FOXM1 inhibition drives β catenin release and nuclear import. FOXM1 de-phosphorylation in response to IM, Vol, Dan and Thio prevents β catenin binding in the cytoplasmic and nuclear compartment of IM-sensitive K562 cells (p < 0.01 or less). β catenin decay following its release from de-phosphorylated FOXM1 is likely driven by nuclear export and cytoplasmic degradation

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