Fig. 5
From: p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma
p65BTK inhibition strongly impairs proliferation and clonogenicity of NSCLC cell lines. a Growth curves of human p53-null NSCLC cell lines treated with increasing concentrations of BTK inhibitors; cell number was evaluated each 24 h by MTT assay. Scale on Y-axis is adapted to the different growth rates shown by each cell line. Data are presented as mean ± SEM. n ≥ 3 independent experiments. * indicates p < 0.05 vs untreated. b Clonogenicity assay of human p53-null NSCLC cell lines treated with increasing concentrations of BTK inhibitors for 10 days. A representative image of one experiment out of 3 is shown