Fig. 2

SP1-mediated gene transcription network is positively correlated with Ajuba expression in multiple cancer types. a Flow chart shows the process of data analysis and transcription factor prediction. In brief, the dysregulated genes in pancreatic ductal adenocarcinoma (PDAC) tissues with lower or higher Ajuba expression from TCGA database were extracted by cBioPortal (http://www.cbioportal.org), and potential ttranscription factor prediction was analyzed using FunRich software. (b, c, d, e) SP1 mediated transcription network is the top hit in PDAC, liver cancer, colon cancer and breast cancer, respectively. f the expression of Ajuba and SP1 is positively correlated in PDAC