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Table 3 Cytofluorimetric determination of autophagy in GBM cells exposed to SI113 and/or QC

From: The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

Cell Line

Control

SI113

QC

SI113 + QC

ADF

60.3 ± 4.2

68.9 ± 4.7

82.3 ± 7.2

99.7 ± 7.1

U373MG

75.4 ± 7.7

82.7 ± 5.4

87.6 ± 5.7

95.4 ± 6.5

T98G

73.3 ± 6.5

92.7 ± 4.4

86.5 ± 4.1

95.4 ± 9.3

GBM3-Luc

59.4 ± 5.6

64.5 ± 5.4

71.9 ± 5.1

94.6 ± 6.7

GBM-I

20.9 ± 2.2

25.8 ± 2.5

28.5 ± 2.1

36.8 ± 2.9

  1. Cytofluorimetric assay for autophagy (see Materials and Methods) in GBM cell lines that were exposed to the drugs as specified in Fig. 4. Autophagic process was quantified by analyzing the median fluorescence intensity values and is expressed as Arbitrary Units
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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