Fig. 1

HCC-associated lncRNAs in histone modification. a HCC-associated lncRNAs recruit histone modifiers to regulate gene expression. Left panel: HOTAIR suppresses miR-218 expression by recruiting PRC2 to miR-218 promoter, which induces chromatin remodeling and H3K27 trimethylation. Right panel: decreased HORAIR inhibits PRC2-mediated miR-218 transcription suppression. b HCC-associated lncRNAs act as scaffold to bridge histone modifiers to regulate gene expression. Left panel: HOTAIR bridges PRC2 complex and Snail, which leads to H3K27 trimethylation in promoter region of Snail target genes. Right panel: decreased HORAIR inhibits PRC2-mediated transcription suppression of Snail target genes