Fig. 6

WZ35 and cisplatin combination inhibited SGC-7901 xenograft tumor growth in vivo, accompanied by decreased TrxR1 activity. (a-b) WZ35 and cisplatin combined treatment significantly inhibited tumor volume and tumor weight (c) of SGC-7901 human gastric cancer xenografts in nude mice. (d) The body weight of nude mice during the experiment. (e) The tumor tissues were lysed and protein was used to determine the TrxR1 activity by using the endpoint insulin reduction assay. (f) The expression levels of Ki-67, Bcl-2, p-p38 and p-JNK proteins in tumor tissues were analyzed by immunohistochemical analysis