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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming

Fig. 4

Hypo-MSC enhances lipogenesis via YAP in HCC cell lines. a Cellular TG levels were detected in 7402 and Hep3b under indicated conditions (n = 3). b The content of neutral lipids was detected by with BODIPY 493/503 dye staining in 7402 and Hep3b under indicated conditions. c The mRNA levels of lipogenic enzymes in 7402 and Hep3b under indicated conditions (n = 3). d Levels of TG in xenograft tumors on different groups (n = 4). e-g Cellular content of TG, neutral lipids and lipogenic enzymes were detected in YAP knockdown (YAP KD) or overexpression (YAP OE) cells. h Cellular content of TG were detected in YAP knockdown (siYAP) cells under indicated conditions (n = 3). i The content of neutral lipids was detected by BODIPY 493/503 dye staining in YAP knockdown (siYAP) cells under indicated conditions. j The mRNA levels of lipogenic enzymes in YAP knockdown (siYAP) cells under indicated conditions (n = 3). (*p < 0.05, **p < 0.01)

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