Fig. 4
From: Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis
Triptolide inhibits Pol III transcription. a RKO cells were incubated with 40 nM triptolide for the indicated time. The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA was measured by real-time qPCR. b RKO cells were incubated with triptolide at the indicated concentration for 0.5 h. The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA was measured by real-time qPCR. c The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA from triptolide-treated and untreated tumors from AOM/DSS mice was measured by real-time qPCR. All the data are presented as the mean ± SD of at least three independent experiments. *P < 0.05, **P < 0.01