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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

Fig. 4

Triptolide inhibits Pol III transcription. a RKO cells were incubated with 40 nM triptolide for the indicated time. The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA was measured by real-time qPCR. b RKO cells were incubated with triptolide at the indicated concentration for 0.5 h. The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA was measured by real-time qPCR. c The mRNA level of 5S rRNA, pre-tRNALeu, pre-tRNATyr, and 7SL RNA from triptolide-treated and untreated tumors from AOM/DSS mice was measured by real-time qPCR. All the data are presented as the mean ± SD of at least three independent experiments. *P < 0.05, **P < 0.01

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