Fig. 3

Ligand-dependent and –independent activation of ER/PR – an impact on patient prognosis in luminal IDC. a ER is activated in response to estrogen. In addition, progesterone induces PR/ER dimerization and recruits ER away from the classical ER-binding sites to the new PR-directed sites, promoting expression of a gene set associated with GOOD PROGNOSIS. b There are two major mechanisms of FGFRs-induced steroid hormone-independent ER/PR regulation, both associated with POOR PROGNOSIS: a FGFRs-triggered shift in ER binding to DNA (ERE, in blue), and FGFRs-dependent rapid activation of ER and PR leading to their subsequent degradation. E – estrogen; ER – estrogen receptor; ERE – estrogen responsive element; P – progesterone; Ub – ubiquitin