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Table 1 Exposure conditions and clinical features of patients recruited for this study

From: Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells

Medium

Age (y)

Gender

Disease

Meana

SDa

Control Medium

–

–

–

0

0

Control Medium

–

–

–

0

0

Control Medium

–

–

–

0

0

Control Medium

–

–

–

0

0

Control Medium

–

–

–

0

0

Exo-CM-HT29

–

–

Colon Cancer Cell Line

0,367

0,039

Exo-CM-HT29

–

–

Colon Cancer Cell Line

0,373

0,048

Exo-CM-HT29

–

–

Colon Cancer Cell Line

0,359

0,019

Exo-CM-HT29

–

–

Colon Cancer Cell Line

0,369

0,016

Exo-CM-HT29

–

–

Colon Cancer Cell Line

0,276

0,025

Control serum 1

30

Male

Healthy

0

0

Control serum 2

35

Female

Healthy

0

0

Control serum 3

42

Female

Healthy

0

0

Control serum 4

41

Male

Healthy

0

0

Control serum 5

37

Male

Healthy

0

0

Control serum 6

30

Female

Healthy

0

0

Control serum 7

33

Female

Healthy

0

0

Control serum 8

35

Male

Healthy

0

0

Control serum 9

39

Female

Healthy

0

0

Control serum 10

38

Male

Healthy

0

0

Control serum 11

45

Male

Healthy

Scratch assay

Control serum 12

39

Female

Healthy

Scratch assay

Control serum 13

28

Male

Healthy

Scratch assay

Exo-Case1

63

Male

Colorectal Cancer

0,509

0,015

Exo-Case2

78

Female

Colorectal Cancer

0,708

0,071

Exo-Case3

65

Male

Colorectal Cancer

0,838

0,074

Exo-Case4

72

Female

Colorectal Cancer

1564

0,256

Exo-Case5

64

Female

Colorectal Cancer

1038

0,162

Exo-Case6

59

Male

Colorectal Cancer

0,200

0,023

Exo-Case7

73

Male

Colorectal Cancer

1440

0,169

Exo-Case8

43

Male

Colorectal Cancer

1331

0,171

Exo-Case9

66

Female

Colorectal Cancer

0,485

0,052

Exo-Case10

63

Female

Colorectal Cancer

0,437

0,033

Exo-Case11

49

Female

Colorectal Cancer

0,341

0,062

Exo-Case12

45

Male

Colorectal Cancer

0,361

0,037

Exo-Case13

66

Male

Colorectal Cancer

1903

0,308

Exo-Case14

66

Male

Colorectal Cancer

Scratch assay

Exo-Case15

61

Female

Colorectal Cancer

Scratch assay

Exo-Case16

46

Female

Colorectal Cancer

Scratch assay

Exo-Case17

49

Male

Colorectal Cancer

Scratch assay

Exo-Case18

56

Male

Colorectal Cancer

Scratch assay

  1. a Size of xenotransplants. BRCA1-KO fibroblasts were treated with different media for 3 weeks. Treated cells were injected subcutaneously into NOD/SCID mice that were followed for 4 weeks for tumors growth. Xenotransplants were measured and data were expressed as mean +/− SD (n = 2–3 mice). P value = 0.0006 when comparing control medium-exposed cells (n = 5) to HT29 cells conditioned medium EVs-exposed cells (n = 5). P value = 0.0074 when comparing healthy serum EVs-treatd cells (n = 10) to cancer patients serum EVs-treated cells (n = 13)
  2. Exo-CM-HT29 and Exo-Case: EVs isolated respectively from HT29 cells conditioned medium and cancer patient’s sera. Conditioned medium was collected from HT29 cells at 80–90% confluence. EVs were isolated by differential ultracentrifugation
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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