Fig. 2

NEO212 inhibited ovarian cancer proliferation in vivo. SK-O-V3 xenograft tumor was established and treated as follows: DMSO, TMZ (25 mg/kg), POH (25 mg/kg), POH (11 mg/kg) mixed with TMZ (14 mg/kg) (mimicking the dosage of the individual components contained in 25 mg/kg TMZ − POH), NEO212 (25 mg/kg). Tumor growth curves (a), tumor image (b) of treated tumors with different treatment were detected. After tumor dissection, tumors were subjected to H&E staining and IHC staining via anti cl-CASP3 (c), tumor weight (d). Mice body weight (e), major organs H&E staining (f) were also evaluated. Scale bars: 50 μm