Fig. 1
From: Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
Ivermectin increased the sensitivity of the cells to chemotherapeutic drugs. a-c The cell viability of sensitive or resistant HCT-8 cells (a), MCF-7 cells (b) and K562 cells (c) after treated with vincristine or adriamycin with or without different concentrations of ivermectin (IVM) for 48 h. Cell viability was determined by MTT assay. The numbers in the figure keys represent the concentrations (μM) of IVM. Cells treated with vehicle serve as a blank control. Abbreviations: IVM, ivermectin; S, vincristine-sensitive HCT-8 cells; R, vincristine-resistant HCT-8 cells; SM, adriamycin-sensitive MCF-7 cells; RM, adriamycin-resistant MCF-7 cells; SK, adriamycin-sensitive K562 cells; RK, adriamycin-resistant K562 cells. All experiments were conducted in quintuplicates and data were expressed as the mean ± SD (n = 5)