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Table 2 Summary of CTLA-4 and PD1

From: Combination of CTLA-4 and PD-1 blockers for treatment of cancer

Receptor CTLA-4 PD-1
Synonyms CD152 PDCD1, CD279
Gene location Chromosome 2q33 Chromosome 2q37.3
Protein details Amino acids #223
Type 1 transmembrane glycoprotein belonging to Ig super family
Domains: a single peptide, an extracellular ligand-binding domain, a transmembrane domain, and a short cytoplasmic tail
Amino acids #288
Type I transmembrane protein belonging to Ig super family
Domains: extracellular N-terminal IgV-like domain, a transmembrane domain, and a cytoplasmic tail
Signaling motif Cytoplasmic tail ITSM
Cells expressing receptor Effector T-cells & TRegs Effector T-cells, TRegs, NK cells & macrophages
Ligands CD80 (B7-1), CD86 (B7-2) PD-L1 (B7-H1), PD-L2 (B7-DC)
Cells expressing ligands APCs APCs, hematopoetic & nonhematopoetic cells & tumor cells