Table 2 Summary of CTLA-4 and PD1
From: Combination of CTLA-4 and PD-1 blockers for treatment of cancer
Receptor | CTLA-4 | PD-1 |
Synonyms | CD152 | PDCD1, CD279 |
Gene location | Chromosome 2q33 | Chromosome 2q37.3 |
Protein details | Amino acids #223 Type 1 transmembrane glycoprotein belonging to Ig super family Dimer Domains: a single peptide, an extracellular ligand-binding domain, a transmembrane domain, and a short cytoplasmic tail | Amino acids #288 Type I transmembrane protein belonging to Ig super family Monomer Domains: extracellular N-terminal IgV-like domain, a transmembrane domain, and a cytoplasmic tail |
Signaling motif | Cytoplasmic tail | ITSM |
Cells expressing receptor | Effector T-cells & TRegs | Effector T-cells, TRegs, NK cells & macrophages |
Ligands | CD80 (B7-1), CD86 (B7-2) | PD-L1 (B7-H1), PD-L2 (B7-DC) |
Cells expressing ligands | APCs | APCs, hematopoetic & nonhematopoetic cells & tumor cells |