Fig. 1
High expression of MUC17 is associated with improved prognosis in GC patient and inflammatory cytokines induce the expression of MUC17 in GC cells. a Higher MUC17 expression was detected in GC tissues compared to normal tissues using information from the TCGA_GC database. The median was shown. b Higher levels of MUC17 expression associated with improved prognosis in patients using information from the TCGA_GC database. c The expression of MUC17 in GC tissues and adjacent normal tissues detected by immunohistochemistry. Scale bar, 50 μM. d High levels of MUC17 expression associated with favourable prognoses in our study cohort. e Co-expression of MUC17 with IL1β and IL8 in GC tissues detected by immunohistochemistry. Scale bar, 50 μM. f Analysis the expression association between MUC17 and IL1β (left) and IL8 (right) by using TCGA_GC transcriptional database. g Treatment with IL1β (left) and IL8 (right) increased the expression of MUC17 determined by RT-PCR. h Treatment with IL1β and IL8 increased the expression of MUC17 determined by qPCR. Error bars represent ± SD of three experiments (*, P < 0.05). i Upper, scheme of MUC17 promoter-luciferase fusion plasmids. Lower, treatment with IL1β and IL8 increased the activity of the MUC17 promoter measured by luciferase assays. Error bars represent ± SD of three experiments (*, P < 0.05)