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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop

Fig. 5

MUC17 protects GC cells against inflammatory stimulation by regulating the p38 pathway. a MUC17 regulated the expression of pJNK, pERK, and pp38 MAPK in MUC17 knocked-down AGS cells (left) and truncated MUC17 overexpressed MKN45 cells (right). b The effect of the p38 inhibitor SB203580 on the expression of NFκB pathway proteins and G2/M phase arrest markers in MUC17 knocked-down AGS cells (left) and truncated MUC17 overexpressed MKN45 cells (right). c SB203580 decreased the effects of MUC17 on inhibiting AGS cells proliferation. d SB203580 decreased the effects of truncated MUC17 on inhibiting MKN45 cells proliferation. e SB203580 decreased the protect effects of MUC17 on AGS cells under inflammatory stimulation. f SB203580 decreased the protect effects of truncated MUC17 on MKN45 cells under inflammatory stimulation. Error bars represent ± SD (#P > 0.05, *P < 0.05; **P < 0.001)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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