Fig. 3
From: CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
CDK5 promotes HCC cell tumorigenic growth and liver metastasis in xenograft implants. a Tumors of GFP-MV and GFP-CDK5 cells grown in nude mouse model; Tumor weight of each group; Tumor volume over the time is shown; t test,*P < 0.05; **P < 0.01;***P < 0.001. b Tumors of nt shScb SMMC-7721 and Cdk5 shRNA SMMC-7721 cells grown in nude mouse model; Tumor weight of each group; Tumor volume over the time is shown; t test,*P < 0.05; **P < 0.01;***P < 0.001. c Liver metastases of GFP-CMV and GFP-CDK5 Huh7 cells grown in nude mouse was shown; Incidence of liver metastasis in each group of nude mice was shown in the right panel. d Liver metastases of shcon and shcdk5 SMMC-7721 cells grown in nude mouse was shown; Incidence of liver metastasis in each group of nude mice was shown in the right panel