Fig. 3

ABCC3 pharmacological inhibition reduces PDAC progression in in vivo mouse models. Mice were injected with HPAFII cells and treated with 25 mg/kg MCI-715 for 28 days as described in Methods section. Data presents the comparison of the tumour growth (a) and survival (b) of HPAFII xenograft mouse model treated with vehicle (n = 4) and MCI-715 (n = 6), Multiple-t-test was performed for statistical analysis of tumour growth, p = 0.0343, Logrank (Mantel-Cox) was performed for statistical analysis of the survival, p = 0.0033; (c) PDX mouse model was created and treated with 25 mg/kg MCI-715 as described in Methods section. Tumour growth in PDX mouse model of pancreatic cancer treated with vehicle (n = 5) and MCI-715 (n = 5) shows significant difference between the two treatment groups. Arrows indicate start and the end of the treatment period, Multiple-t-test was performed for statistical analysis of tumour growth *p < 0.05; (d) KPC transgenic mouse model was treated with 25 mg/kg MCI-715 as described in Methods section. Kaplan Meier survival curve of KPC mice treated with vehicle (n = 8) and MIC-715 (n = 6). Logrank (Mantel-Cox) test was performed for statistical analysis, p = 0.0010