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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway

Fig. 1

LUCAT1 is over-expressed in the BCSCs compared to BCCs and related to BC stemness. a Heat maps of differential lncRNAs between MCF-7 CSCs and MCF-7 in microarray expression profile. b mRNA expression level of LUCAT1 in MCF-10A, MCF-7 and MCF-7 CSCs detected by qRT-PCR. c RT-qPCR was performed to measure the relative expression of LUCAT1 in nuclear and cytoplasm. The majority of LUCAT1 was located in the cytoplasm according to the nuclear mass separation assay. d mRNA expression level of LUCAT1 in patients with CD44 + CD24- phenotype and others from RNA sequencing data of TCGA database. e mRNA expression level of OCT4 in LUCAT1-high and LUCAT1-low patients from TCGA database. f mRNA expression level of ABCC1 in LUCAT1-high and LUCAT1-low patients from TCGA database. g mRNA expression level of Wnt1 in LUCAT1-high and LUCAT1-low patients from TCGA database. h mRNA expression level of HIF-1α in LUCAT1-high and LUCAT1-low patients from TCGA database. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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