Fig. 5

DU145R80-derived LO promote DU145 tumor engraftment in xenograft nude mice and have been found in tumor tissues from mice. a Tumor incidence in mice injected with DU145 cells (1/7), DU145R80 cells (7/7), DU145 cells treated with 80 μg/μL of either LO145 (1/7) or LOR80 (4/7). T-Student test: ***p < 0.0001 (DU145R80 vs all groups), **p = 0.0001 (LOR80 vs DU145). b Survival of the mice xenografted with the different cell lines by Kaplan-Meyer analysis. ***p < 0.0001 (c) CK18 and (d) αV-integrin immunohystochemistry staining of xenograft tumours. Arrows indicate LO-like vesicles of 1–5 μm diameter