Fig. 5

Notch1 enhance the activity of AKT/mTOR pathway and CXCL12/CXCR4 axis. a-b Decreased protein level of Hes1 (Notch1 pathway downstream factors), CXCR4, p-AKT and p-mTOR were measured by western blot after blockage of Notch1 signaling by shRNA-Notch1 and MK0752 in U87GICs and U251GICs. c-d The relative phosphorylation of AKT and mTOR were shown respectively. (*P < 0.05, **P < 0.01, ***P < 0.001)