Fig. 10

Hsa_circ_0058124/NOTCH3/GATAD2A axis promotes PTC tumor formation in vivo. a TPC-1 cells with indicated transfection (3 × 10⁶ cells per mouse, n = 5 for each group) were inoculated into nude mice to establish subcutaneous xenograft tumors. The mice were sacrificed at 27 days. The dissected tumors were photographed. Representative macroscopic views showed the tumors in the indicated groups. b Tumor sizes were measured every 3 days after the tumors were palpable. c, d Dissected tumor volumes and weights were measured at 27 days. e Schematic model of depicting hsa_circ_0058124 as an oncogene in PTC. ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001