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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Fig. 7

The potential immunological mechanism of sFGL2 in HCC development. sFGL2 attenuates DC activity by inhibiting Akt signaling and induces DCs into a regulatory state. sFGL2 blockage results in attenuated DC expression of CD83 and MHCII and increased expression of CD31, which hinders DC-mediated stimulation of CD8+ T cells and Th1 cells. Decreased production of granzyme B and perforin from CD8+ T cells exacerbates immunosuppression in the HCC microenvironment. Additionally, the number of Tregs increases along with elevated IL-35 levels. The immunological balance in HCC is thereby disrupted, resulting in dominant immunosuppression and tumor progression

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