Fig. 4

PAX8 regulates functions of tumor promotion of MACC1-AS1 in PC cells. a and b Increased cell livability in PC cells with over-expressed MACC1-AS1 was restored via knocking PAX8 down, but the reduction of the activity of PC cells with silenced MACC1-AS1 was abolished via the overexpression of PAX8. We detected the cell viability with CCK-8 assays. c and d MACC1-AS1–induced cell migration was partially hurdled by PAX8 knockdown, whereas the decreased cell motility in PC cells with silenced MACC1-AS1 was rescued via the overexpression of PAX8. P < 0.05; P < 0.01