Fig. 2
From: GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway
The stress-induced pro-apoptotic effect of GKN2 on GC cell lines. a-b Analyses of apoptosis with or without H2O2 (300 uM) concentration for 6 h in GC cell lines. c-d Comparison of colony formation in MGC and SGC cells with or without H2O2 (300 uM) pre-treatment for 6 h. e Analyses of cell cycle after PI staining in GC cell lines after H2O2 (300 uM) treatment for 6 h. Data are presented as the mean of three independent experiments. f Comparison of proliferation in MGC and SGC cells with or without H2O2 (300 uM) pre-treatment for 6 h. GKN2 overexpressing MGC cells (IC50 528.4 ± 29.5 μM) and SGC cells (IC50 539.2 ± 31.6 μM) were significantly more sensitive to H2O2 compared to control MGC cells (IC50 660.4 ± 29.4 μM, P < 0.01) and SGC cells (IC50 663.0 ± 25.6 μM, P < 0.01), respectively. Data are presented as mean ± SD from three independent experiments with each running in triplicate. (n = 3, **p < 0.01, ***p < 0.001)