Fig. 4

M802 inhibited proliferation and enhanced apoptosis of tumor cells in vitro. (a) M802 or Herceptin were incubated with SK-BR-3 cells (a), BT-474 cells (b), or JIMT-1 cells (c). After 48 h, cells were stained with Annexin V/PI and fluorescence was measured using flow cytometry. (b) Analysis of the fold-change of apoptosis in the treatment groups relative to the control group. The apoptosis ratios were significantly greater in SK-BR-3 cells (a, *P < 0.05) and the BT-474 cells (b, **P < 0.01), but not the JIMT-1 cells (c)