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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer

Fig. 4

FLVCR1-AS1 regulated miR-513 expression in OSC cells. a miR-513 expression was significantly upregulated after FLVCR1-AS1 knockdown. b, c miR-513 overexpression and inhibition were transfected into SKOV3 and OVCAR3 cells, and the transfection efficiency was verified using qRT-PCR. d, e FLVCR1-AS1 mRNA expression was significantly decreased in response to miR-513 overexpression while increased in response to miR-513 inhibition. f miR-513 expression levels were significantly decreased in human OSC tissues compared with adjacent normal tissues. g An inverse correlation was observed between mRNA expressions of miR-513 and FLVCR1-AS1 in human OSC tissues. h FLVCR1-AS1 interacted with miR-513 by directly targeting. i CCK8 results showed that FLVCR1-AS1 were significantly downregulated in FLVCR1-AS1 knockdown groups compared to the si-NC group, while the effects were reversed by miR-513 inhibition cotransfected groups. The data were presented as mean ± SD of three independent experiments. **P < 0.01

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