Table 2 Survivin outgoing signal networka: molecules that are regulated by survivin
Mechanism and Effects | Classified Factors/Molecules |
|---|---|
1. Survivin binds to the molecule for activation | Transporter: ABCG2. Kinase: Aurora-B, CDK1 (p34), CDK4, DNA-PK. Phosphatase: CDC25B. Binding protein: INCENP, NET1 (TSPAN1), XIAP. |
2. Survivin transcriptionally regulates the molecule for activation | Receptor kinase: c-kit. Kinase: IKK-beta. |
3. Survivin affects the molecule expression for activation | Binding protein: Cyclin D1, Cyclin E. Transcription factor: HIF1A. Protease: MMP-9. Receptor ligand: VEGF-A. |
4. Survivin binds to the molecule for inhibition | Protease: Caspase-3, Caspase-7, Caspase-9. Transcription factor: STAT3. |
5. Survivin transcriptionally regulates the molecule for inhibition | Enzyme: Dicer. |
6. Unspecified inhibition | Protease: Caspase-8. |
7. Survivin affects the molecule expression for inhibition | Receptor-kinase: DR5 (TNFRSF10B). |
8. Homodimerization for survivin stabilization | Binding protein: survivin |
9. Survivin binds to the molecule with unspecified effects | Binding protein: AIP, Bcl-2, Birc6, C7orf59k, CARD5, CDCA8, Clathrin heavy chain, Cyclin B1, Eps15, Histone H2AX, Histone H3, HSP90α, Ku70, MED18, MED29, MED6, MED8, NFBD1, p53BP1, Rb protein, Smac (Diablo), SRB7, SURF5, TRAP170, TRAP18, TRAP25, TRAP80, TRFP, TRG20, Tubulin, Tubulin-β, VDRIP. Kinase: Aurora-A, CDK2. Protein: CCDC102A. Transcription factor: E2F4, E2F5, TRIP2. GTPase: G-protein α-i3, Ran. Transporter: HBZ. Protease: HtrA2, p17 CASP3. Protein: JTB. Receptor: SSC5D. |
10. Survivin transcriptionally regulates the molecule with unspecified effects | Transcription factor: BLIMP1 (PRDI-BF1), p53. miRNA: miR-520b. Binding protein: p21. |