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Table 2 Survivin outgoing signal networka: molecules that are regulated by survivin

From: Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?

Mechanism and Effects Classified Factors/Molecules
1. Survivin binds to the molecule for activation Transporter: ABCG2. Kinase: Aurora-B, CDK1 (p34), CDK4, DNA-PK. Phosphatase: CDC25B. Binding protein: INCENP, NET1 (TSPAN1), XIAP.
2. Survivin transcriptionally regulates the molecule for activation Receptor kinase: c-kit. Kinase: IKK-beta.
3. Survivin affects the molecule expression for activation Binding protein: Cyclin D1, Cyclin E. Transcription factor: HIF1A. Protease: MMP-9. Receptor ligand: VEGF-A.
4. Survivin binds to the molecule for inhibition Protease: Caspase-3, Caspase-7, Caspase-9. Transcription factor: STAT3.
5. Survivin transcriptionally regulates the molecule for inhibition Enzyme: Dicer.
6. Unspecified inhibition Protease: Caspase-8.
7. Survivin affects the molecule expression for inhibition Receptor-kinase: DR5 (TNFRSF10B).
8. Homodimerization for survivin stabilization Binding protein: survivin
9. Survivin binds to the molecule with unspecified effects Binding protein: AIP, Bcl-2, Birc6, C7orf59k, CARD5, CDCA8, Clathrin heavy chain, Cyclin B1, Eps15, Histone H2AX, Histone H3, HSP90α, Ku70, MED18, MED29, MED6, MED8, NFBD1, p53BP1, Rb protein, Smac (Diablo), SRB7, SURF5, TRAP170, TRAP18, TRAP25, TRAP80, TRFP, TRG20, Tubulin, Tubulin-β, VDRIP. Kinase: Aurora-A, CDK2. Protein: CCDC102A. Transcription factor: E2F4, E2F5, TRIP2. GTPase: G-protein α-i3, Ran. Transporter: HBZ. Protease: HtrA2, p17 CASP3. Protein: JTB. Receptor: SSC5D.
10. Survivin transcriptionally regulates the molecule with unspecified effects Transcription factor: BLIMP1 (PRDI-BF1), p53. miRNA: miR-520b. Binding protein: p21.
  1. aInformation was retrieved from the GeneGo database at https://portal.genego.com/ and organized by the authors. Relevant references for each finding can be found in the database from the corresponding molecule under the “link info”.