Fig. 7
Upregulation of LINC00460 and PRDX1 was correlated with poor clinicopathologic features in HNSCC patients. a The relative expression of LINC00460 in HNSCC tissues (Tumor) and their adjacent normal tissues (Adjacent) was detected by qRT-PCR. ****p < 0.0001, n = 123. b LINC00460 expression was classified into two groups according to the expression ratio (T/N) of tumor tissue (T) to adjacent normal tissue (N) in HNSCC tissue. c The relative expression of PRDX1 in HNSCC tissues (Tumor) and their adjacent normal tissues (Adjacent) was detected by qRT-PCR. *p < 0.05, n = 123. d PRDX1 expression was classified into two groups according to the expression ratio (T/N) of HNSCC tumor tissue (T) to adjacent normal tissue (N). e The associations between the relative expression of LINC00460 and lymph metastasis/pathological differentiation were investigated in patients with HNSCC. p < 0.05. f The association between the relative expression of PRDX1 and tumor size was investigated in patients with HNSCC. p < 0.05. g Images of IHC staining of PRDX1 in normal oral mucosa and oral squamous cell carcinoma are shown. h Pearson correlation analysis of the expression of LINC00460 and PRDX1 in HNSCC tissue. p < 0.0001, r = 0.322, n = 143. i A proposed model illustrating the modulatory role of LINC00460 and PRDX1 in regulating HNSCC cell proliferation and metastasis