Fig. 5

In vivo anticancer properties of CBP. a) Antitumor effect of CBP in a xenograft model of MM. The tumor growth curves show that CBP was able to significantly delay the growth of the ectopic tumors as compared to the controls (p-value = 0.0013), but with lower efficacy, compared to cisplatin (p-value = 0.0011). b) Effects of CBP on cell proliferation apoptosis and angiogenesis as compared to the control, as determined by Ki67, TUNEL (asterisks identify apoptotic cells) and CD34 staining (original magnification × 10). CBP treatment significantly decreased cell proliferation (25% vs 10%; p-value = 0.008), increased apoptosis (8% vs 2%; p-value = 0.0005) and decreased angiogenesis (5 ± 2 vs 10 ± 4; p-value = 0.0006)