Fig. 7From: S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathwaySystemic diagram of the mechanism of S1PR1/STAT3 signaling pathway. S1PR1 regulated the phosphorylation of STAT3 through directly binding to STAT3. Then phosphorylated STAT3 transferred into the nucleus to regulate the transcription of downstream target genes, leading to proliferation promotion and apoptosis inhibition of ESCC cellsBack to article page