Fig. 5

Assessed globally, GISTIC2.0 analysis identified a higher number of recurrent somatic copy number alterations (SCNA) in the CYT-low subset of colon (but not rectum) adenocarcinomas. a The genome plots depict the loci with significantly recurrent amplifications (red) and deletions (blue), among CYT-high and CYT-low COAD tumors, respectively. b Bubble plots display the summarized GISTIC results for each cytolytic subset in the COAD cohort. Significantly, amplified or deleted samples across the COAD dataset are depicted in red and blue colors, respectively. The x-axis depicts the number of samples and the y-axis depicts the number of genes. The size of the bubbles corresponds to the level of the calculated q-values (−log₁₀(q-value)) for the aberrant genomic regions. c The number of the total recurrent SCNA events was significantly higher in the cytolytic-low COAD subset (p = 5.07e-3, Mann–Whitney). d The genome plots depict the loci with significantly recurrent amplifications (red) and deletions (blue), among CYT-high and CYT-low READ tumors, respectively. e Bubble plots display the summarized GISTIC results for each cytolytic subset in the READ cohort. Significantly, amplified or deleted samples across the READ dataset are depicted in red and blue colors, respectively. The x-axis depicts the number of samples and the y-axis depicts the number of genes. The size of the bubbles corresponds to the level of the calculated q-values (−log₁₀(q-value)) for the aberrant genomic regions. f The number of the total recurrent SCNA events was higher in the cytolytic-low READ subset, but the difference was not statistically significant (p = 0.188, Mann–Whitney)