Fig. 3

MAZ promotes bone metastasis of PC-3 cells a Representative BLIs signal of bone metastasis of a mouse from the indicated groups of mice at 12 mins and 8 weeks respectively. b Representative radiographic images of bone metastases in the indicated mice (arrows indicate osteolytic lesions). c Representative H&E-stained sections of tibias from the indicated mouse. d The sum of bone metastasis score for each mouse in tumor-bearing mice inoculated with vector (n = 10), MAZ (n = 10), scramble(n = 10) and sh-MAZ-1# (n = 10) cells. *P < 0.05. e Quantification of the BLI signaling in the vector, MAZ, scramble and sh-MAZ-1# groups at 25, 35,45,55 and 65 days respectively. *P < 0.05. T-test was not conducted on days 55 and 65 due to the death of a large number of mice. f Kaplan-Meyer analysis of mouse survival in the vector, MAZ, scramble and sh-MAZ-1# groups (Gehan-Breslow-Wilcoxon Test). (G) Kaplan-Meyer analysis of mouse bone metastasis-free survival in the vector, MAZ, scramble and sh-MAZ-1# groups (Gehan-Breslow-Wilcoxon Test)