Fig. 7

Clinical correlations of MAZ with KRas and activated RalA in human PCa tissues. a-c Immunohistochemical (IHC) staining of MAZ, KRas and HRas protein expression in representative samples of PCa/nBM, PCa/BM and bone were shown. d Analysis of MAZ expression with KRas and activated RalA in 3 bone metastatic PCa tissues, 3 nonbone metastatic PCa tissues, and 3 metastatic bone tissues. We sequentially numbered each group of cases, and then randomly selected 3 cases in each group. Total RalA and α-tubulin were used as a loading control. e Hypothetical model illustrating that overexpression of MAZ activates KRas and RalGEFS, leading to the bone metastasis of PCa