Fig. 5
From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma
RNF187 is critical for Notch1-mediated HCC migration, invasion and EMT. a Western blotting assays were used to detect the expression of Notch1, RNF187, Vimentin, E-cadherin, and Snai1. b Migration and invasion assays in PLC/PRF5-Notch1 and HCCLM6-shNotch1 cells following RNF187 modulation. c Immunofluorescent staining assay of E-cadherin and Vimentin expressions in PLC/PRF5-Notch1 and HCCLM6-shNotch1 with RNF187 modulation. d Representative IHC images of Notch1, RNF187, Vimentin, E-cadherin, and Snail expression in the xenograft orthotopic liver tumors derived from HCCLM6-shNotch1 and their control cells. *: P <  0.05. Magnification: 400 ×