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Table 1 Association of Notch1 expression with clinicopathological factors of the HCC patients in cohort I and cohort II

From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Clinicopathological variables Cohort I Cohort II
n Notch1 expression aP value n Notch1 expression aP value
Low (n = 75) High (n = 75) Low (n = 36) High (n = 31)
Sex Male 122 61 61 1.000 54 31 23 0.219
Female 28 14 14 13 5 8
Age, years ≤ 50 63 35 28 0.247 38 17 21 0.091
>  50 87 40 47 29 19 10
Serum AFP, ng/mL ≤ 20 63 33 30 0.620 23 12 11 0.853
>  20 87 42 45 44 24 20
Tumor nodule number Solitary 123 60 63 0.524 52 28 24 0.972
Multiple 27 15 12 15 8 7
Maximal tumor size, cm ≤ 5 69 35 34 0.870 37 21 16 0.581
>  5 81 40 41 30 15 15
Microvascular invasion Absent 68 40 28 0.049 39 24 15 0.130
Present 82 35 47 28 12 16
Tumor differentiation Well 19 9 10 0.806 22 14 8 0.256
Moderately or poorly 131 66 65 45 22 23
TNM stage I and II 97 49 48 0.864 47 26 21 0.689
III and IV 53 26 27 20 10 10
  1. a Pearson chi-square test was used for comparison between subgroups. Significant results (P < 0.05) are given in bold