An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Table 1 Association of Notch1 expression with clinicopathological factors of the HCC patients in cohort I and cohort II

Clinicopathological variables		Cohort I				Cohort II
		n	Notch1 expression		^aP value	n	Notch1 expression		^aP value
		n	Low (n = 75)	High (n = 75)	^aP value	n	Low (n = 36)	High (n = 31)	^aP value
Sex	Male	122	61	61	1.000	54	31	23	0.219
Sex	Female	28	14	14	1.000	13	5	8	0.219
Age, years	≤ 50	63	35	28	0.247	38	17	21	0.091
Age, years	> 50	87	40	47	0.247	29	19	10	0.091
Serum AFP, ng/mL	≤ 20	63	33	30	0.620	23	12	11	0.853
Serum AFP, ng/mL	> 20	87	42	45	0.620	44	24	20	0.853
Tumor nodule number	Solitary	123	60	63	0.524	52	28	24	0.972
Tumor nodule number	Multiple	27	15	12	0.524	15	8	7	0.972
Maximal tumor size, cm	≤ 5	69	35	34	0.870	37	21	16	0.581
Maximal tumor size, cm	> 5	81	40	41	0.870	30	15	15	0.581
Microvascular invasion	Absent	68	40	28	0.049	39	24	15	0.130
Microvascular invasion	Present	82	35	47	0.049	28	12	16	0.130
Tumor differentiation	Well	19	9	10	0.806	22	14	8	0.256
Tumor differentiation	Moderately or poorly	131	66	65	0.806	45	22	23	0.256
TNM stage	I and II	97	49	48	0.864	47	26	21	0.689
TNM stage	III and IV	53	26	27	0.864	20	10	10	0.689

^a Pearson chi-square test was used for comparison between subgroups. Significant results (P < 0.05) are given in bold

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