From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma
Clinicopathological variables | Cohort I | Cohort II | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Univariate analysis | ||||
 Age, years (> 50 vs. ≤50) | 0.714 (0.437–1.166) | 0.178 | 0.939 (0.483–1.827) | 0.853 |
 Sex (male vs. female) | 1.268 (0.701–2.294) | 0.433 | 0.696 (0.289–1.680) | 0.421 |
 Serum AFP, ng/mL (> 20 vs. ≤20) | 1.785 (1.058–3.011) | 0.030 | 0.689 (0.352–1.348) | 0.277 |
 Tumor nodule number (multiple vs. solitary) | 2.912 (1.712–4.953) | < 0.001 | 1.247 (0.564–2.759) | 0.585 |
 Maximal tumor size, cm (>  5 vs. ≤ 5) | 5.712 (2.978–10.955) | < 0.001 | 1.962 (1.006–3.829) | 0.048 |
 Microvascular invasion (present vs. absent) | 6.060 (3.155–11.643) | < 0.001 | 1.223 (0.623–2.399) | 0.558 |
 Tumor differentiation (moderately or poorly vs. well) | 12.369 (1.714–89.245) | 0.013 | 0.879 (0.441–1.752) | 0.714 |
 TNM stage (III and IV vs. I and II) | 4.739 (2.842–7.902) | <  0.001 | 0.865 (0.405–1.850) | 0.709 |
 Combination of Notch1 and RNF187 | ||||
  A vs. D | 0.276 (0.136–0.600) | < 0.001 | 0.230 (0.074–0.717) | 0.011 |
  B vs. D | 0.451 (0.231–0.879) | 0.019 | 0.680 (0.292–1.581) | 0.370 |
  C vs. D | 0.599 (0.312–1.148) | 0.123 | 0.557 (0.233–1.332) | 0.188 |
Multivariate analysis | ||||
 Serum AFP, ng/mL (> 20 vs. ≤20) | 1.164 (0.664–2.039) | 0.596 | NA | NA |
 Tumor nodule number (multiple vs. solitary) | 1.818 (1.000–3.303) | 0.050 | NA | NA |
 Maximal tumor size, cm (>  5 vs. ≤ 5) | 2.405 (1.085–5.333) | 0.031 | 1.914 (0.937–3.913) | 0.075 |
 Vascular invasion (present vs. absent) | 2.942 (1.413–6.125) | 0.004 | NA | NA |
 Tumor differentiation (moderately or poorly vs. well) | 3.141 (0.395–24.985) | 0.279 | NA | NA |
 TNM stage (III and IV vs. I and II) | 1.791 (0.928–3.457) | 0.082 | NA | NA |
 Combination of Notch1 and RNF187 | ||||
  A vs. D | 0.327 (0.156–0.685) | 0.003 | 0.263 (0.084–0.828) | 0.022 |
  B vs. D | 0.862 (0.425–1.748) | 0.681 | 0.884 (0.363–2.154) | 0.786 |
  C vs. D | 0.769 (0.375–1.576) | 0.473 | 0.702 (0.283–1.738) | 0.444 |