Skip to main content

Table 3 Univariate and multivariate analyses of risk factors associated DFS of HCC patients in cohort I and cohort II

From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Clinicopathological variables

Cohort I

Cohort II

HR (95% CI)

P value

HR (95% CI)

P value

Univariate analysis

 Age, years (> 50 vs. ≤50)

0.714 (0.437–1.166)

0.178

0.939 (0.483–1.827)

0.853

 Sex (male vs. female)

1.268 (0.701–2.294)

0.433

0.696 (0.289–1.680)

0.421

 Serum AFP, ng/mL (> 20 vs. ≤20)

1.785 (1.058–3.011)

0.030

0.689 (0.352–1.348)

0.277

 Tumor nodule number (multiple vs. solitary)

2.912 (1.712–4.953)

< 0.001

1.247 (0.564–2.759)

0.585

 Maximal tumor size, cm (>  5 vs. ≤ 5)

5.712 (2.978–10.955)

< 0.001

1.962 (1.006–3.829)

0.048

 Microvascular invasion (present vs. absent)

6.060 (3.155–11.643)

< 0.001

1.223 (0.623–2.399)

0.558

 Tumor differentiation (moderately or poorly vs. well)

12.369 (1.714–89.245)

0.013

0.879 (0.441–1.752)

0.714

 TNM stage (III and IV vs. I and II)

4.739 (2.842–7.902)

<  0.001

0.865 (0.405–1.850)

0.709

 Combination of Notch1 and RNF187

  A vs. D

0.276 (0.136–0.600)

< 0.001

0.230 (0.074–0.717)

0.011

  B vs. D

0.451 (0.231–0.879)

0.019

0.680 (0.292–1.581)

0.370

  C vs. D

0.599 (0.312–1.148)

0.123

0.557 (0.233–1.332)

0.188

Multivariate analysis

 Serum AFP, ng/mL (> 20 vs. ≤20)

1.164 (0.664–2.039)

0.596

NA

NA

 Tumor nodule number (multiple vs. solitary)

1.818 (1.000–3.303)

0.050

NA

NA

 Maximal tumor size, cm (>  5 vs. ≤ 5)

2.405 (1.085–5.333)

0.031

1.914 (0.937–3.913)

0.075

 Vascular invasion (present vs. absent)

2.942 (1.413–6.125)

0.004

NA

NA

 Tumor differentiation (moderately or poorly vs. well)

3.141 (0.395–24.985)

0.279

NA

NA

 TNM stage (III and IV vs. I and II)

1.791 (0.928–3.457)

0.082

NA

NA

 Combination of Notch1 and RNF187

  A vs. D

0.327 (0.156–0.685)

0.003

0.263 (0.084–0.828)

0.022

  B vs. D

0.862 (0.425–1.748)

0.681

0.884 (0.363–2.154)

0.786

  C vs. D

0.769 (0.375–1.576)

0.473

0.702 (0.283–1.738)

0.444

  1. Significant results (P < 0.05) are given in bold. Combination of Notch1 and RNF187: A, Notch1 (low) & RNF187 (low); B, Notch1 (high) & RNF187 (low); C, Notch1 (low) & RNF187 (high); D, Notch1 (high) & RNF187 (high)