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Table 3 Univariate and multivariate analyses of risk factors associated DFS of HCC patients in cohort I and cohort II

From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Clinicopathological variables Cohort I Cohort II
HR (95% CI) P value HR (95% CI) P value
Univariate analysis
 Age, years (> 50 vs. ≤50) 0.714 (0.437–1.166) 0.178 0.939 (0.483–1.827) 0.853
 Sex (male vs. female) 1.268 (0.701–2.294) 0.433 0.696 (0.289–1.680) 0.421
 Serum AFP, ng/mL (> 20 vs. ≤20) 1.785 (1.058–3.011) 0.030 0.689 (0.352–1.348) 0.277
 Tumor nodule number (multiple vs. solitary) 2.912 (1.712–4.953) < 0.001 1.247 (0.564–2.759) 0.585
 Maximal tumor size, cm (>  5 vs. ≤ 5) 5.712 (2.978–10.955) < 0.001 1.962 (1.006–3.829) 0.048
 Microvascular invasion (present vs. absent) 6.060 (3.155–11.643) < 0.001 1.223 (0.623–2.399) 0.558
 Tumor differentiation (moderately or poorly vs. well) 12.369 (1.714–89.245) 0.013 0.879 (0.441–1.752) 0.714
 TNM stage (III and IV vs. I and II) 4.739 (2.842–7.902) <  0.001 0.865 (0.405–1.850) 0.709
 Combination of Notch1 and RNF187
  A vs. D 0.276 (0.136–0.600) < 0.001 0.230 (0.074–0.717) 0.011
  B vs. D 0.451 (0.231–0.879) 0.019 0.680 (0.292–1.581) 0.370
  C vs. D 0.599 (0.312–1.148) 0.123 0.557 (0.233–1.332) 0.188
Multivariate analysis
 Serum AFP, ng/mL (> 20 vs. ≤20) 1.164 (0.664–2.039) 0.596 NA NA
 Tumor nodule number (multiple vs. solitary) 1.818 (1.000–3.303) 0.050 NA NA
 Maximal tumor size, cm (>  5 vs. ≤ 5) 2.405 (1.085–5.333) 0.031 1.914 (0.937–3.913) 0.075
 Vascular invasion (present vs. absent) 2.942 (1.413–6.125) 0.004 NA NA
 Tumor differentiation (moderately or poorly vs. well) 3.141 (0.395–24.985) 0.279 NA NA
 TNM stage (III and IV vs. I and II) 1.791 (0.928–3.457) 0.082 NA NA
 Combination of Notch1 and RNF187
  A vs. D 0.327 (0.156–0.685) 0.003 0.263 (0.084–0.828) 0.022
  B vs. D 0.862 (0.425–1.748) 0.681 0.884 (0.363–2.154) 0.786
  C vs. D 0.769 (0.375–1.576) 0.473 0.702 (0.283–1.738) 0.444
  1. Significant results (P < 0.05) are given in bold. Combination of Notch1 and RNF187: A, Notch1 (low) & RNF187 (low); B, Notch1 (high) & RNF187 (low); C, Notch1 (low) & RNF187 (high); D, Notch1 (high) & RNF187 (high)